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A case of Trientine Overdose.
1Digestive Diseases Centre, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom.
Toxicology International
|February 11, 2016
Summary
Trientin overdose in Wilson disease showed a good safety profile. This suggests trientine may be a viable first-line treatment for patients with psychiatric complications.
Area of Science:
- Hepatology
- Neurology
- Pharmacology
Background:
- Wilson disease is a rare genetic disorder characterized by excessive copper accumulation in the liver and brain.
- Current treatment guidelines typically recommend trientine as a second-line therapy for Wilson disease management.
- The safety profile of high-dose trientine in overdose scenarios requires further elucidation.
Observation:
- A case study involving a significant overdose of trientine (60 g) in a patient was documented.
- The patient experienced self-limiting symptoms of dizziness and vomiting following the overdose.
- No lasting clinical effects or notable biochemical changes were observed post-ingestion.
Findings:
- The overdose of trientine did not result in severe adverse events or lasting health issues.
- The observed symptoms were transient and resolved without specific medical intervention.
- Biochemical markers remained within normal limits, indicating no significant organ damage.
Implications:
- This case highlights the favorable safety profile of trientine, even at high doses.
- The findings support the potential use of trientine as a first-line treatment for Wilson disease.
- Consideration of trientine as a first-line option may be particularly beneficial for patients with psychiatric comorbidities or those at risk of self-harm.
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