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Allergen immunotherapy for allergic asthma: protocol for a systematic review
Sangeeta Dhami1, Ulugbek Nurmatov2, Ioana Agache3
1Evidence-Based Health Care Ltd, Edinburgh, UK.
Clinical and Translational Allergy
|February 11, 2016
Summary
This systematic review assesses allergen immunotherapy (AIT) for allergic asthma management. Findings will guide the European Academy of Allergy and Clinical Immunology (EAACI) guidelines on AIT effectiveness, cost-effectiveness, and safety.
Area of Science:
- Allergy and Clinical Immunology
- Respiratory Medicine
Background:
- The European Academy of Allergy and Clinical Immunology (EAACI) is developing guidelines for allergen immunotherapy (AIT) in allergic asthma.
- A critical assessment of AIT's effectiveness, cost-effectiveness, and safety is needed for asthma management.
Purpose of the Study:
- To systematically review the evidence on allergen immunotherapy (AIT) for allergic asthma.
- To inform the development of EAACI's clinical guidelines for AIT in allergic asthma.
Main Methods:
- A systematic review of international biomedical databases.
- Inclusion of published, in-progress, and unpublished evidence.
- Independent screening, critical appraisal, and data synthesis (descriptive and quantitative).
Main Results:
- Evidence synthesis on AIT effectiveness for allergic asthma.
- Evaluation of AIT's cost-effectiveness in asthma management.
- Assessment of AIT's safety profile in allergic asthma patients.
Conclusions:
- Findings will directly inform EAACI's forthcoming guidelines on AIT for allergic asthma.
- Recommendations will be evidence-based, focusing on optimal patient care.

