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Related Concept Videos

Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Related Experiment Video

Updated: Mar 26, 2026

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
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Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

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Accumulative eschar after burn.

Fushun Ma1

  • 1Surgeon of Plastic Surgery Hospital of Weifang Medical University 288 Shenglidongjie Kuiwen Weifang Shandong 261042 China.

Clinical Case Reports
|February 11, 2016
PubMed
Summary

For persistent burn eschar on fingertips, topical recombinant human basic fibroblast growth factor (rb-bFGF) after debridement offers an optimal treatment outcome. This approach aids wound healing when skin grafting or reepithelialization is challenging.

Keywords:
Accumulative escharfibroblast growth factorgranulation woundhand burn

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Area of Science:

  • Wound healing research
  • Burn injury management
  • Regenerative medicine

Background:

  • Eschar formation is a common complication following burn injuries.
  • Standard treatments include escharectomy and debridement, followed by skin grafting or promoting reepithelialization.
  • Persistent, refractory eschar, particularly on fingertips, presents a significant clinical challenge.

Observation:

  • The study focuses on managing prolonged and refractory eschar on the fingertips.
  • It investigates the efficacy of topical recombinant human basic fibroblast growth factor (rb-bFGF) post-debridement.

Findings:

  • Topical application of rb-bFGF after eschar debridement can lead to optimal outcomes for refractory fingertip eschar.
  • This method provides a viable alternative when conventional healing methods are insufficient.

Implications:

  • This finding suggests a promising therapeutic option for severe burn cases involving fingertips.
  • It highlights the potential of growth factor therapy in reconstructive surgery and burn care.
  • Further research may explore rb-bFGF's role in other challenging wound scenarios.