Related Experiment Video
Updated: Mar 26, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
21.1K
Enlarging mediastinal/hilar lymphadenopathy with calcification
Takashi Adachi1, Masashi Nakahata2, Suzuko Moritani3
1Department of Respiratory Medicine National Hospital Organization Higashinagoya National Hospital 5-101 Umemorizaka, Meito-ku Nagoya Aichi 468-8620 Japan.
Clinical Case Reports
|February 11, 2016
Summary
This case study highlights how endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) successfully diagnosed mediastinal amyloidosis in a patient with enlarged lymph nodes. This technique proved crucial for identifying the condition.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Mediastinal and hilar lymphadenopathy with calcification can indicate various underlying conditions.
- Amyloidosis is a rare condition characterized by the buildup of abnormal proteins in organs.
- Monoclonal gammopathy of undetermined significance (MGUS) is a precursor to plasma cell disorders.
Purpose of the Study:
- To report a case of mediastinal amyloidosis diagnosed using EBUS-TBNA.
- To illustrate the diagnostic utility of EBUS-TBNA in complex lymphadenopathy cases.
- To highlight the association between MGUS and mediastinal amyloidosis.
Main Methods:
- Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) of mediastinal/hilar lymph nodes.
- Bone marrow aspiration for hematological evaluation.
- Histopathological and immunohistochemical analysis of aspirated samples.
Main Results:
- EBUS-TBNA provided tissue samples diagnostic of amyloidosis.
- The patient was diagnosed with mediastinal amyloidosis associated with MGUS.
- Calcification in lymphadenopathy was a key imaging finding.
Conclusions:
- EBUS-TBNA is an effective minimally invasive technique for diagnosing mediastinal amyloidosis.
- Early diagnosis of amyloidosis is critical for patient management.
- The association between MGUS and mediastinal amyloidosis underscores the importance of comprehensive hematological assessment.
Related Concept Videos
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
405
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
405
01:15Secondary Lymphoid Organs
10.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.2K
01:22Mitral Stenosis I: Introduction
1.2K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.2K
01:31Pulmonary Tuberculosis III
1.3K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.3K
01:23Detailed Structure and Function of Lymph Nodes
6.2K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
6.2K
01:26Pulmonary Tuberculosis IV
628
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
628