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Updated: Mar 26, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
Overview, prevention and management of chemotherapy extravasation
Firas Y Kreidieh1, Hiba A Moukadem1, Nagi S El Saghir1
1Firas Y Kreidieh, Hiba A Moukadem, Nagi S El Saghir, Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Riad El Solh 1107 2020, Beirut, Lebanon.
Abstract:
Chemotherapy extravasation remains an accidental complication of chemotherapy administration and may result in serious damage to patients. We review in this article the clinical aspects of chemotherapy extravasation and latest advances in definitions, classification, prevention, management and guidelines. We review the grading of extravasation and tissue damage according to various chemotherapeutic drugs and present an update on treatment and new antidotes including dexrazoxane for anthracyclines extravasation. We highlight the importance of education and training of the oncology team for prevention and prompt pharmacological and non-pharmacological management and stress the availability of new antidotes like dexrazoxane wherever anthracyclines are being infused.
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