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Published on: October 16, 2010
Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type
Anastasia M Konstantinova1, Michal Michal, Denisa Kacerovska
1*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint-Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; §Bioptical Laboratory, Pilsen, Czech Republic; ¶PathWest Laboratory Medicine WA, QEII Medical Centre, Nedlands, Australia; ‖School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Australia; **PathWest Laboratory Medicine WA, King Edward Memorial Hospital, Perth, Australia; ††Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany; ‡‡Clinical Department of Dermatology and Venereology, Medical University Innsbruck, Innsbruck, Austria; §§Division of Dermatopathology, Department of Pathology, Medical College of Wisconsin, Milwaukee, WI; ¶¶Dermatopathology Institute, Zürich, Switzerland; ‖‖Department of Pathology, Institute for the Care of Mother and Child, Prague, Czech Republic; ***Department of Pathology, Petrov's Research Institute of Oncology, Saint-Petersburg, Russia; †††Unit of Anatomic Pathology, School of Biomedical Sciences, Etromapmacs Pole, Lesina (FG), Italy; ‡‡‡Cytopathos Laboratory, Bratislava, Slovak Republic; §§§Agel Laboratory of Pathology, Novy Jicin, Czech Republic; and ¶¶¶Department of Dermatology, Zurich University Hospital, Zurich, Switzerland.
Abstract:
Hidradenoma papilliferum (HP), also known as papillary hidradenoma, is the most common benign lesion of the female anogenital area derived from anogenital mammary-like glands (AGMLG). HP can be viewed conceptually as the cutaneous counterpart of mammary intraductal papilloma. The authors have studied 264 cases of HP, detailing various changes in the tumor and adjacent AGMLG, with emphasis on mammary-type alterations. In many HP, the authors noticed changes typical for benign breast lesions, such as sclerosing adenosis-like changes, usual, and atypical ductal hyperplasia. Almost in a third of cases, remnants of AGMLG adjacent to the lesion were evident, manifesting columnar changes reminiscent of those seen in breast lesions. This study shows that the histopathological changes in HP run a broad spectrum comparable with that in the mammary counterpart and benign breast disease.
