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Updated: Mar 26, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
Published on: July 27, 2022
Facile rhenium-peptide conjugate synthesis using a one-pot derived Re(CO)3 reagent
Kullapa Chanawanno1, Vinay Kondeti, Joel Caporoso
1Department of Chemistry, University of Akron, OH 44325-3601, USA. ziegler@uakron.edu.
Abstract:
We have synthesized two Re(CO)3-modified lysine complexes (1 and 2), where the metal is attached to the amino acid at the Nε position, via a one-pot Schiff base formation reaction. These compounds can be used in the solid phase synthesis of peptides, and to date we have produced four conjugate systems incorporating neurotensin, bombesin, leutenizing hormone releasing hormone, and a nuclear localization sequence. We observed uptake into human umbilical vascular endothelial cells as well as differential uptake depending on peptide sequence identity, as characterized by fluorescence and rhenium elemental analysis.
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