Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

4.2K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
4.2K
Guidelines and Strategies for Safe Computer Charting01:18

Guidelines and Strategies for Safe Computer Charting

3.1K
The guidelines and strategies provided by the American Nurses Association (ANA) and the Canadian Nurses Association (CNA) offer essential principles for ensuring safe and secure computer charting systems in healthcare settings. Let's break down each recommendation:
Maintain Confidentiality and Security:
3.1K
Crossing Over01:30

Crossing Over

7.2K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
7.2K
Crossing Over01:34

Crossing Over

174.1K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
174.1K
Standards of Care II01:19

Standards of Care II

1.2K
Nurses bear specific legal responsibilities under several federal statutes, including:
1.2K
SBAR I: Understanding the Concept01:29

SBAR I: Understanding the Concept

6.8K
Effective communication among healthcare professionals during hand-off reporting is essential to delivering safe and continuous patient care. Common professional interactions include reports to healthcare team members, hand-off, and transfer reports. Nurses routinely report information to other healthcare team members and also urgently contact healthcare providers to report changes in patient status.
Standardized methods of communication have been developed to ensure that information is...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Causality analysis of toxicological mechanisms in networked systems such as adverse outcome pathway networks.

Archives of toxicology·2026
Same author

Green toxicology only becomes beautiful through AI.

Frontiers in chemistry·2026
Same author

AI snake oil? A risk/benefit analysis for toxicology.

Frontiers in artificial intelligence·2026
Same author

Ensuring continued access to essential inhaled respiratory medications: a call to action from the Inhaled Respiratory medicine Innovation and environmental Sustainability (IRIS) group.

The European respiratory journal·2026
Same author

Low-dose inorganic arsenic exposure reprograms macrophages differentiation and function toward tumor-promoting phenotypes.

Environmental research·2026
Same author

ToxiVerse: A Public Platform for Chemical Toxicity Data Sharing and Customizable Predictive Modeling.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Mar 26, 2026

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
04:36

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum

Published on: August 5, 2020

5.1K

Toward Good Read-Across Practice (GRAP) guidance.

Nicholas Ball1, Mark T D Cronin2, Jie Shen3

  • 1The Dow Chemical Company, Midland, MI, USA.

ALTEX
|February 11, 2016
PubMed
Summary
This summary is machine-generated.

Read-across for chemical safety assessments groups substances using structural and mechanistic data. This review clarifies its application under REACH regulations, addressing challenges and providing guidance for effective use.

Keywords:
chemical similaritycomputational toxicologyhazard assessmentread-acrossuncertainty

More Related Videos

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices
08:53

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

19.2K
Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior
06:38

Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior

Published on: June 9, 2020

5.4K

Related Experiment Videos

Last Updated: Mar 26, 2026

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
04:36

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum

Published on: August 5, 2020

5.1K
Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices
08:53

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

19.2K
Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior
06:38

Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior

Published on: June 9, 2020

5.4K

Area of Science:

  • Chemical safety assessment
  • Toxicology
  • Regulatory science

Background:

  • Read-across is a key data gap filling technique in chemical safety assessments.
  • Grouping substances based on structural and mechanistic similarity is crucial.
  • Lack of consensus on evidence requirements hinders read-across acceptance by regulatory authorities.

Purpose of the Study:

  • Summarize the state-of-the-art in read-across methodology.
  • Analyze European Chemicals Agency (ECHA) decisions to identify successes and pitfalls of read-across under REACH.
  • Compile relevant activities and guidance documents to facilitate read-across application.

Main Methods:

  • Review of ECHA's published decisions on compliance checks and testing proposals.
  • Analysis of existing tools and approaches for read-across.
  • Examination of uncertainty, biological data, and the ECHA Read-Across Assessment Framework (RAAF).

Main Results:

  • Identified common challenges and successful strategies in read-across applications under REACH.
  • Highlighted the importance of mechanistic data and robust uncertainty assessment.
  • Evaluated the impact of the ECHA Read-Across Assessment Framework (RAAF) on regulatory acceptance.

Conclusions:

  • Read-across is a valuable tool for chemical safety, but clear guidelines and consensus on evidence are needed.
  • Effective read-across requires careful consideration of structural and mechanistic similarities, uncertainty, and supporting data.
  • Further harmonization and knowledge sharing can improve the consistent application and regulatory acceptance of read-across.