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Progressive postresection program (pPRP) after pancreatic resection: study protocol for a randomized controlled

Susanne Richter1, Verena Uslar2, Navid Tabriz3

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This summary is machine-generated.

Intensive physiotherapy after pancreatic resection may improve quality of life for patients with pancreatic cancer. Further multicenter studies are needed to confirm these findings for improved patient outcomes.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Rehabilitation Medicine

Background:

  • Pancreatic cancer has a poor prognosis, with only 15-20% of patients diagnosed with resectable disease.
  • Limited progression-free and overall survival necessitate strategies to enhance patients' quality of life.
  • Developing effective post-surgical rehabilitation programs is crucial for improving patient well-being.

Purpose of the Study:

  • To evaluate the impact of an intensified physiotherapy program on the quality of life in patients following pancreatic resection.
  • To compare the effectiveness of intensive physiotherapy against standard physiotherapy in the post-operative recovery phase.
  • To establish a structured follow-up protocol including imaging for patients undergoing pancreatic resection.

Main Methods:

  • A randomized controlled trial involving 60 patients undergoing pancreatic resection.
  • Intervention group (n=30) received intensified physiotherapy (endurance and muscle force exercises).
  • Control group (n=30) received standard physiotherapy, with both groups receiving dietary counseling and pancreatic insufficiency management. Quality of life assessed using SF-8 and EORTC QLQ-C30/QLQ-PAN26 questionnaires.

Main Results:

  • The study aims to determine if intensive physiotherapy leads to significant improvements in patient-reported quality of life.
  • Analysis will focus on differences in quality of life scores between the intensive physiotherapy and standard physiotherapy groups.
  • Postoperative abdominal CT scans at 6 and 12 months will monitor disease progression.

Conclusions:

  • The primary goal is to ascertain if intensive physiotherapy enhances the quality of life for patients after pancreatic resection.
  • Positive findings would support a larger, statistically powered multicenter study.
  • The study establishes a progressive postresection program with structured follow-up.