Bacteriuria in representative population samples of persons aged 72-79 years

Area of Science:

• Gerontology
• Infectious Diseases
• Microbiology

Background:

• Bacteriuria, the presence of bacteria in urine, is common in the elderly.
• Previous studies have varied in their findings regarding the persistence and clinical significance of bacteriuria in this demographic.

Purpose of the Study:

• To determine the frequency and persistence of bacteriuria in a representative elderly population.
• To identify factors, such as bacterial species and counts, associated with persistent bacteriuria.

Main Methods:

• A population-based screening for bacteriuria was conducted in individuals aged 72-79 years in Göteborg, Sweden.
• Repeated screenings were performed to detect new cases and assess persistence.
• Bacteriuric individuals were monitored, and untreated cases were analyzed for bacterial characteristics and clearance.

Main Results:

• Initial screening showed bacteriuria in 6-16% of men and women aged 72 and 79 years.
• Repeated screening identified additional cases, highlighting the dynamic nature of bacteriuria.
• Escherichia coli (E. coli) with counts ≥10^6/ml were significantly more likely to persist (77%) compared to non-E. coli strains or lower E. coli counts.
• Persistent bacteriuria, especially E. coli, was predominantly observed in women.

Conclusions:

• Screening for high bacterial counts (≥10^6/ml) of E. coli is the most effective method for detecting persistent bacteriuria in the general elderly population.
• Understanding bacterial load and species is crucial for predicting bacteriuria persistence in older adults.