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Vitamin D (soltriol), light, and reproduction
1Department of Cell Biology, University of North Carolina, Chapel Hill 27599.
American Journal of Obstetrics and Gynecology
|November 1, 1989
Summary
The steroid hormone 1,25(OH)2-vitamin D3 (soltriol) plays a crucial role in regulating reproductive functions in both females and males. Evidence suggests its involvement in puberty, fertility, pregnancy, and lactation.
Area of Science:
- Endocrinology
- Reproductive Biology
- Nutritional Science
Background:
- 1,25(OH)2-vitamin D3 (soltriol) is a steroid hormone with known roles beyond calcium homeostasis.
- Nuclear receptors for soltriol are present in various reproductive tissues and endocrine glands.
Purpose of the Study:
- To review evidence on the role of soltriol in regulating female and male reproductive processes.
- To highlight the importance of soltriol in seasonal adaptation, growth, development, and procreation.
Main Methods:
- Review of autoradiographic studies using tritium-labeled soltriol.
- Analysis of existing literature, including experimental, clinical, and epidemiologic data.
Main Results:
- Soltriol regulates and modulates reproductive processes in both sexes.
- Nuclear receptors for soltriol are found in the uterus, ovary, pituitary, and other reproductive-related tissues.
- Soltriol is involved in puberty onset, fertility, pregnancy, lactation, and sexual behavior.
Conclusions:
- Soltriol is a key hormonal messenger, influenced by sunlight, vital for reproductive health.
- Cooperative interactions between soltriol and other steroid hormones, like estradiol, are significant for reproductive function.