Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Triphasic Randomized Clinical Trial: comparative frequency of intermenstrual bleeding.

W Droegemueller1, L R Katta, T G Bright

  • 1Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill 27599-7590.

American Journal of Obstetrics and Gynecology
|November 1, 1989
PubMed
Summary

Patient compliance with oral contraceptives is key. A clinical trial found significant differences in intermenstrual bleeding between different triphasic oral contraceptives, impacting discontinuation rates.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Building a comprehensive clinical information system from components. The approach at Intermountain Health Care.

Methods of information in medicine·2003
Same author

Clinical experience reported by candidates for the American Board of Obstetrics and Gynecology 1995 and 1997 oral examinations.

American journal of obstetrics and gynecology·2001
Same author

A faculty development course in obstetrics and gynecology.

American journal of obstetrics and gynecology·2000
Same author

Obstetrician-gynecologists as primary care providers? How North Carolina HMOs decide.

North Carolina medical journal·1999
Same author

Time to discard the cookie cutter.

American journal of obstetrics and gynecology·1999
Same author

Managing labor--never walk alone.

The New England journal of medicine·1998

Area of Science:

  • Reproductive Health
  • Pharmacology
  • Clinical Trials

Background:

  • Oral contraceptives (OCs) offer high theoretical efficacy but practical failure rates are influenced by patient compliance.
  • Intermenstrual bleeding, a common side effect, significantly contributes to OC discontinuation.

Purpose of the Study:

  • To compare the incidence of intermenstrual bleeding among three different triphasic oral contraceptives.
  • To assess the impact of specific formulations on patient adherence and side effect profiles.

Main Methods:

  • A randomized clinical trial involving three groups of subjects using different triphasic oral contraceptives: NET (A) (Ortho-Novum 7/7/7), LNG (Tri-Levlen), and NET (B) (Tri-Norinyl).
  • Incidence of intermenstrual bleeding (breakthrough bleeding or spotting) was recorded and compared between groups.

Related Experiment Videos

  • A control group experienced no breakthrough bleeding and a 4% incidence of spotting.

    • Main Results:

    • The incidence of intermenstrual bleeding was highest in the NET (A) group (63%), followed by NET (B) (44%), and LNG (33%).
    • The difference in bleeding incidence between NET (A) and LNG was statistically significant (p < 0.030).

    Conclusions:

    • Formulation of triphasic oral contraceptives significantly influences the occurrence of intermenstrual bleeding.
    • Further research is needed to elucidate the reasons for observed disparities in side effect incidence among different OCs.