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Related Experiment Video

Updated: Mar 26, 2026

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Novel device, a temporary guidewire fixator.

Linus Bosaeus1, Kevin Mani2, Anders Wanhainen2

  • 1Endovascular Development Ltd., Uppsala, Sweden linus.bosaeus@endovab.com.

Vascular
|February 12, 2016
PubMed
Summary
This summary is machine-generated.

A novel guidewire fixation device demonstrated safety and functionality in a pig model, showing successful deployment, retrieval, and no adverse effects on blood flow. This innovative device ensures uninterrupted circulation during procedures.

Keywords:
Guidewireanimal testdislocation forcefenestrated endovascular aneurysm repairfixatorretrieval

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Area of Science:

  • Biomedical Engineering
  • Interventional Cardiology
  • Medical Device Development

Background:

  • Guidewire manipulation is critical in interventional procedures.
  • Secure distal fixation of guidewires is essential for device stability and patient safety.
  • Existing methods may pose risks or limitations in certain clinical scenarios.

Purpose of the Study:

  • To evaluate the safety and functionality of a novel distal guidewire fixation device.
  • To assess device performance in terms of deployment, retrieval, blood flow compatibility, and fixation strength.
  • To determine the device's potential for clinical application in vascular interventions.

Main Methods:

  • A novel distal guidewire fixation device was tested in an established pig model.
  • Procedures involved anesthesia, heparinization, device deployment, 4-hour blood stream deposition, and retrieval.
  • Assessment included angiography for blood flow, thrombus inspection, and measurement of displacement force.

Main Results:

  • The device was successfully deployed and retrieved in over 40 instances, with one bailout retrieval case.
  • Angiography confirmed uninterrupted blood flow during 4-hour deposition, with no arterial occlusion or thrombosis.
  • The median displacement force was 7.6 N, and no arterial rupture or dissection occurred post-fixation loss.

Conclusions:

  • The novel distal guidewire fixation device proved to be safe and functional in the tested animal model.
  • The device maintained blood flow and demonstrated adequate fixation strength without causing vascular damage.
  • Results support the potential clinical utility of this device in vascular interventions requiring guidewire stability.