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Screening applications in drug discovery based on microfluidic technology.

P Eribol1, A K Uguz1, K O Ulgen1

  • 1Department of Chemical Engineering, Boğaziçi University , 34342 Bebek, Istanbul, Turkey.

Biomicrofluidics
|February 12, 2016
PubMed
Summary

Microfluidic technology offers significant advantages for pharmaceutical drug screening, including reduced analysis time and chemical usage. Despite 20 years of development, further innovation in microfluidic systems like organs-on-chips is crucial for efficient drug discovery.

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Area of Science:

  • * Microfluidics and its application in pharmaceutical research.
  • * Development of lab-on-a-chip systems for drug discovery.

Background:

  • * Microfluidic technology offers advantages like reduced analysis time, low chemical consumption, and high throughput.
  • * The pharmaceutical industry faces lengthy and expensive drug screening and commercialization processes.

Purpose of the Study:

  • * To review microfluidic methods for drug candidate screening.
  • * To focus on fabrication, flow types, kinetic parameter determination, toxicity assessment, and computational methods.

Main Methods:

  • * Review of microfluidic fabrication techniques and materials.
  • * Analysis of continuous and discrete flow advantages.
  • * Examination of kinetic parameter determination and comparison with conventional systems.
  • * Assessment of toxicity and cytotoxicity using microfluidic devices.
  • * Evaluation of concentration generation for high-throughput screening and computational methods.

Main Results:

  • * Microfluidic technology enables efficient drug screening with enhanced control over mass and heat transfer.
  • * Applications include kinetic parameter determination, toxicity assessment, and high-throughput concentration generation.
  • * Recent advancements include microengineered organs-on-chips and organ arrays.

Conclusions:

  • * Microfluidic technology has matured over 20 years but still presents opportunities for research and development.
  • * Innovative design and problem-solving are essential for advancing microfluidic applications in drug discovery.
  • * Organs-on-chips represent a significant extension of microfluidic systems for pharmaceutical research.