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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
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Does an Insulin Double-Checking Procedure Improve Patient Safety?

Mary Beth Modic1, Nancy M Albert, Zhiyuan Sun

  • 1Author Affiliations: Clinical Nurse Specialist (Dr Modic), Office of Nursing Education and Professional Practice Development, Cleveland Clinic; Associate Chief Nursing Officer (Dr Albert), Office of Nursing Research and Innovation, Biostatistician (Mr Sun), Quantitative Health Sciences, and Biostatistician (Mr Bena), Quantitative Health Sciences, Cleveland Clinic Health System; and Volunteer (Ms Yager), Department of Volunteer Services, Clinical Nurse Specialists (Mss Cary, Corniello, Kaser, Simon, and Skowronsky), and Clinical Instructor (Mr Kissinger), Office of Nursing Education and Professional Practice Development, Cleveland Clinic, Ohio.

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Summary

A subcutaneous insulin double-checking intervention reduced administration errors, though timing mistakes persisted. This study highlights the need for improved strategies to prevent all types of insulin errors.

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Area of Science:

  • Pharmacology
  • Patient Safety
  • Healthcare Quality Improvement

Background:

  • Insulin administration errors constitute 3.5% of medication errors.
  • Leading healthcare organizations recommend a two-nurse double-checking process for insulin preparation.
  • This underscores the critical need for interventions to improve insulin administration safety.

Purpose of the Study:

  • To evaluate the efficacy of a subcutaneous insulin double-checking preparation intervention.
  • To determine its impact on reducing insulin administration errors.
  • To identify specific error types affected by the intervention.

Main Methods:

  • A randomized, controlled, nonblinded, intent-to-treat study design was employed.
  • Data were collected over four weeks involving 266 patients and 5238 insulin administration opportunities.
  • Comparison was made between a double-checking group and a usual care group.

Main Results:

  • The double-checking group demonstrated a higher incidence of error-free insulin administrations compared to usual care.
  • Wrong-time errors were the most frequent type but were less prevalent in the double-checking group.
  • Omission errors were infrequent and also reduced in the double-checking group.

Conclusions:

  • The subcutaneous insulin double-checking preparation procedure effectively reduced overall insulin administration errors.
  • However, the intervention did not resolve the predominant timing errors.
  • Further research is needed to address persistent timing-related insulin administration errors.