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Expression of Matrix Metalloproteinases-2/-9 is Associated With Microvessel Density in Pancreatic Cancer

Tinghai Xiang1, Xiuliang Xia, Wenyan Yan

  • 11Department of Hepatobiliary Surgery, Binzhou People's Hospital, Binzhou, Shandong, China; and 2Section II, Department of Neurology, Binzhou People's Hospital, Binzhou, Shandong, China.

American Journal of Therapeutics
|February 12, 2016
PubMed

Insights

Matrix-metalloproteinases (MMP)-2 and MMP-9 are elevated in pancreatic cancer tissues, correlating with increased microvessel density (MVD). These findings suggest MMPs play a role in pancreatic cancer angiogenesis and could be potential therapeutic targets.

Area of Science:

  • Oncology
  • Pathology
  • Biochemistry

Background:

  • Pancreatic cancer is characterized by rapid angiogenesis.
  • Matrix-metalloproteinases (MMPs), particularly MMP-2 and MMP-9, are implicated in tumor growth and metastasis.
  • The relationship between MMP expression and microvessel density (MVD) in pancreatic cancer requires further elucidation.

Purpose of the Study:

  • To investigate the association between matrix-metalloproteinase (MMP)-2 and MMP-9 expression and microvessel density (MVD) in pancreatic cancer.
  • To analyze the correlation of MMP-2 and MMP-9 with clinicopathological features of pancreatic cancer.

Main Methods:

  • Immunohistochemistry was used to evaluate MMP-2 and MMP-9 expression in tumor tissues, para-tumor tissues, and normal pancreatic tissues from 30 pancreatic cancer patients and 17 controls.
  • Microvessel density (MVD) was assessed and correlated with MMP expression scores and pathological staging (TNM).

Main Results:

  • Significantly higher positive expression rates of MMP-2 and MMP-9 were observed in pancreatic tumor tissues compared to para-tumor tissues (P < 0.01).
  • MMP-2 and MMP-9 expression was negative in normal pancreatic tissues.
  • MVD values showed a significant positive correlation with MMP-2 scores (r = 0.563, P < 0.05) and MMP-9 scores (r = 0.451, P < 0.05).
  • MVD increased significantly with advanced tumor node metastasis (TNM) stages (P = 0.04).

Conclusions:

  • MMP-2 and MMP-9 expression is significantly associated with angiogenesis in pancreatic cancer.
  • Elevated MMPs correlate with increased MVD and advanced disease stages.
  • MMPs represent potential prognostic biomarkers and therapeutic targets for pancreatic cancer.

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