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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Sorazolons, Carbazole Alkaloids from Sorangium cellulosum Strain Soce375
Sabrina Karwehl1,2, Rolf Jansen1,2, Volker Huch3
1Department of Microbial Drugs, Helmholtz Centre for Infection Research , Inhoffenstraße 7, 38124 Braunschweig, Germany.
Abstract:
Sorazolons A (1) to E2 (9) were isolated from Sorangium cellulosum strain Soce375. Their molecular structures were elucidated using extensive HRESIMS and NMR analysis. The absolute configuration of sorazolon A (1) was determined by comparison of the experimental CD spectrum with quantum chemical calculated spectra for both enantiomers. Sorazolons D2 (7), E (8), and E2 (9) exhibit a moderate cytotoxic activity against mouse fibroblast cell line L929 with IC50 values between 5.0 μM and 0.09 mM.
