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Updated: Jul 27, 2026

Methods for Intravenous Self Administration in a Mouse Model
Published on: December 8, 2012
Dose and elasticity of demand for self-administered cocaine in rats
David N Kearns1, Alan Silberberg
1Department of Psychology, American University, Washington, DC, USA.
Abstract:
The present experiment tested whether the elasticity of demand for self-administered cocaine in rats is dose-dependent. Subjects lever pressed for three different doses of intravenous cocaine - 0.11, 0.33, and 1.0 mg/kg/infusion - on a demand procedure where the number of lever presses required per infusion increased within a session. The main finding was that demand for the 0.11 mg/kg dose was more elastic than it was for the two larger doses. There was no difference in demand elasticity between the 0.33 and 1.0 mg/kg doses. These results parallel findings previously reported in monkeys. The present study also demonstrated that a within-session procedure can be used to generate reliable demand curves.
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