Related Experiment Video

Updated: Mar 26, 2026

Quantification of Colonic Stem Cell Mutations
07:53

Quantification of Colonic Stem Cell Mutations

Published on: September 25, 2015

7.1K

Prevalence of glucose-6-phosphate dehydrogenase deficiency in jaundiced Egyptian neonates

Wafaa Moustafa M Abo El Fotoh1, Mohammed Soliman Rizk2

  • 1a Department of Pediatrics , Menoufia University , Shebin El-Kom , Egypt and.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|February 12, 2016
PubMed

Insights

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a significant cause of neonatal hyperbilirubinemia, particularly in males. This condition impairs red blood cell function, leading to jaundice and potentially kernicterus.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Genetics

Background:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency impairs reduced glutathione production, increasing red blood cell susceptibility to oxidative damage and hemolysis.
  • Neonatal G6PD deficiency can manifest as severe hyperbilirubinemia and kernicterus.

Purpose of the Study:

  • To investigate the prevalence and impact of erythrocyte G6PD deficiency in neonates presenting with hyperbilirubinemia.
  • To establish a correlation between G6PD deficiency and the severity of neonatal jaundice.

Main Methods:

  • A cohort of 202 neonates with indirect hyperbilirubinemia were analyzed.
  • G6PD activity was quantified using the UV-Kinetic Method via spectrophotometry.
  • Demographic data and clinical parameters, including serum total bilirubin levels, were recorded.

Main Results:

  • Eighteen neonates (8.9%) were diagnosed with G6PD deficiency, exclusively in males.
  • A positive correlation was observed between the onset of jaundice and G6PD levels in deficient neonates.
  • Mean serum total bilirubin was elevated in G6PD-deficient cases.

Conclusions:

  • G6PD deficiency is a notable contributor to neonatal jaundice, particularly when jaundice appears on or after the second day of life.
  • Early detection of G6PD deficiency is crucial for managing neonatal hyperbilirubinemia and preventing complications.
Abstract

Keywords:
Glucose-6-phosphate dehydrogenaseRHhemolysishyperbilirubinemia

More Related Videos

Measuring Uptake of the Glucose Analog, 6-(N-(7-Nitrobenz-2-Oxa-1,3-Diazol-4-yl)Amino)-6-Deoxyglucose, in Intact Murine Neural Retina07:04

Measuring Uptake of the Glucose Analog, 6-(N-(7-Nitrobenz-2-Oxa-1,3-Diazol-4-yl)Amino)-6-Deoxyglucose, in Intact Murine Neural Retina

Published on: March 14, 2025

899
Biochemical Measurement of Neonatal Hypoxia13:13

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

14.5K

Related Concept Videos

Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
28.2K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
1.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.3K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.4K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
5.1K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.3K