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Related Experiment Videos

Correlation between Doppler flow velocity waveforms and cord blood viscosity.

S A Steel1, J M Pearce, G Nash

  • 1Department of Obstetrics, St George's Hospital Medical School, London.

British Journal of Obstetrics and Gynaecology
|October 1, 1989
PubMed
Summary

Plasma viscosity significantly correlates with umbilical artery resistance index in pregnancies. However, this rheological factor is unlikely to be clinically significant for blood flow impedance.

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Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Physiology
  • Medical Ultrasound

Background:

  • Umbilical artery impedance reflects fetal well-being and placental function.
  • Rheological properties of blood can influence hemodynamics.
  • Continuous-wave Doppler ultrasound is a non-invasive tool for assessing fetal circulation.

Purpose of the Study:

  • To investigate the contribution of rheological factors, specifically plasma viscosity and whole blood viscosity, to umbilical artery blood flow impedance.
  • To determine the correlation between plasma viscosity, gestational age, and the resistance index.
  • To assess the clinical significance of rheological factors in umbilical artery impedance.

Main Methods:

  • Recruitment of 51 pregnancies, including controls and those with pre-eclampsia and/or intrauterine growth retardation.

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  • Utilizing continuous-wave Doppler ultrasound to measure the resistance index of the umbilical artery.
  • Employing multiple regression analysis to evaluate the impact of plasma viscosity on the resistance index.

    • Main Results:

    • A significant correlation was found between plasma viscosity, gestational age, and the umbilical artery resistance index.
    • Plasma viscosity changes explained a statistically significant 55% of the variance in the resistance index.
    • Whole blood viscosity demonstrated an insignificant effect on umbilical artery impedance.

    Conclusions:

    • While plasma viscosity is significantly correlated with umbilical artery impedance, its clinical significance is questionable.
    • Vascular factors, such as placental arteriole characteristics, are likely more critical determinants of umbilical artery impedance.
    • Further research into placental vascularity is warranted to fully understand umbilical artery blood flow regulation.