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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.3K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Skeletal Muscle Relaxants: Therapeutic Uses01:31

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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
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Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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Muscle Contraction01:15

Muscle Contraction

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Muscle Contraction01:10

Muscle Contraction

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In skeletal muscles, acetylcholine is released by nerve terminals at the motor endplate—the point of synaptic communication between motor neurons and muscle fibers. The binding of acetylcholine to its receptors on the sarcolemma allows entry of sodium ions into the cell and triggers an action potential in the muscle cell. Thus, electrical signals from the brain are transmitted to the muscle. Subsequently, the enzyme acetylcholinesterase breaks down acetylcholine to prevent excessive...
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Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
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Related Experiment Video

Updated: Mar 25, 2026

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice
14:36

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice

Published on: February 9, 2013

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Contractures and muscle disease.

R Jon Walters

    Practical Neurology
    |February 13, 2016
    PubMed
    Summary

    Contractures are key indicators in muscle diseases, aiding diagnosis alongside weakness. Recognizing contractures is crucial as they are linked to myopathies, some with cardiac issues, offering diagnostic insights.

    Area of Science:

    • Neurology
    • Clinical Diagnostics
    • Muscle Diseases

    Background:

    • Contractures are significant clinical signs observed in various muscle diseases.
    • Their presence, alongside muscle weakness patterns, aids in diagnosing specific myopathies.
    • Certain myopathies associated with contractures also present with critical cardiac manifestations.

    Purpose of the Study:

    • To highlight the diagnostic utility of contractures in myopathies.
    • To emphasize the importance of recognizing contractures due to their association with cardiac involvement.
    • To underscore the potential of contractures as a pivotal diagnostic clue.

    Main Methods:

    • Clinical observation and analysis of patient data.
    • Review of literature on myopathies and associated contractures.
    Keywords:
    myopathy contracture

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    Related Experiment Videos

    Last Updated: Mar 25, 2026

    Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice
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  • Correlation of clinical signs with diagnostic outcomes.

    • Main Results:

    • Contractures serve as valuable indicators in the diagnostic process for muscle diseases.
    • The presence of contractures is frequently associated with myopathies, including those with cardiac complications.
    • Identifying contractures can lead to a more rapid and accurate diagnosis.

    Conclusions:

    • Contractures are important diagnostic markers in myopathies.
    • Recognition of contractures is essential for identifying potential cardiac risks.
    • Contractures offer a significant diagnostic advantage in the evaluation of muscle disorders.