TAM receptor tyrosine kinase function and the immunopathology of liver disease
S K Mukherjee1, A Wilhelm1, C G Antoniades2
1Division of Digestive Diseases, Department of Medicine, Imperial College London, London, United Kingdom; and.
Abstract:
Tyro3, Axl, MERTK (TAM) receptor tyrosine kinases are implicated in the regulation of the innate immune response through clearance of apoptotic cellular debris and control of cytokine signaling cascades. As a result they are pivotal in regulating the inflammatory response to tissue injury. Within the liver, immune regulatory signaling is employed to prevent the overactivation of innate immunity in response to continual antigenic challenge from the gastrointestinal tract. In this review we appraise current understanding of the role of TAM receptor function in the regulation of both innate and adaptive immunity, with a focus on its impact upon hepatic inflammatory pathology.
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