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Published on: July 13, 2017
Serum Antibodies to Glycans in Peripheral Neuropathies
Sandro Sonnino1, Elena Chiricozzi2, Maria Grazia Ciampa2
1Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy. sandro.sonnino@unimi.it.
Abstract:
In peripheral neuropathies, such as sensorimotor neuropathies, motor neuron diseases, or the Guillain-Barré syndrome, serum antibodies recognizing saccharide units, portion of oligosaccharides, or oligosaccharide chains, have been found. These antibodies are called anti-glycosphingolipid (GSL) or anti-ganglioside antibodies. However, the information on the aglycone carrying the hydrophilic oligosaccharide remains elusive. The absolute and unique association of GSL to the onset, development and symptomatology of the peripheral neuropathies could be misleading. Here, we report some thoughts on the matter.
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