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Related Experiment Video

Updated: Mar 25, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

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Published on: June 26, 2018

Multisensory body representation in autoimmune diseases.

Gianluca Finotti¹, Marcello Costantini^1,2

¹Laboratory of Neuropsychology and Cognitive Neuroscience, Department of Neuroscience, Imaging and Clinical Sciences, University G. d'Annunzio, Chieti, Italy &Institute for Advanced Biomedical Technologies - ITAB, University G. d'Annunzio, Chieti, Italy.

Scientific Reports

|February 13, 2016

Summary

The Rubber Hand Illusion (RHI), a measure of body ownership, is enhanced in individuals with Coeliac Disease (CD). This suggests the immune system influences multisensory integration and body representation.

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Area of Science:

Neuroscience
Psychology
Immunology

Background:

Body representation relies on multisensory signal integration.
The Rubber Hand Illusion (RHI) demonstrates multisensory influence on body ownership.
Variability in RHI susceptibility is not well understood.

Purpose of the Study:

To investigate the role of the immune system in RHI susceptibility.
To explore potential links between immune function and body representation.

Main Methods:

Comparison of RHI susceptibility between Coeliac Disease (CD) patients and healthy controls.
Exploration of potential biochemical mechanisms.

Main Results:

RHI was significantly stronger in CD patients compared to healthy controls.
This finding supports a link between immune system functioning and multisensory body representation.

Conclusions:

Immune system activity, as altered in CD, can modulate multisensory integration and body ownership.
Findings suggest a biochemical mechanism connecting the immune system and body representation.
Implications for conditions involving altered multisensory processing, body representation, and immune dysfunction.