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Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Related Experiment Video

Updated: Mar 25, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Migraine and endothelial function: The HUNT3 Study.

Joakim Schjølberg Larsen1, Eli-Anne Skaug2, Ulrik Wisløff2,3

  • 1Department of Neuroscience, Norwegian University of Science and Technology, Norway.

Cephalalgia : an International Journal of Headache
|February 13, 2016
PubMed
Summary
This summary is machine-generated.

This study found no link between endothelial function, measured by flow-mediated dilatation (FMD), and common headache disorders, including migraine. These findings suggest migraine may not impact vascular health in otherwise healthy individuals.

Keywords:
Migraineendothelial dysfunctionendothelial functionflow-mediated dilatationheadache

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Area of Science:

  • Vascular Biology
  • Neurology
  • Epidemiology

Background:

  • Endothelial dysfunction is a risk factor for cardiovascular disease.
  • Previous research on migraine and endothelial function has yielded conflicting results.
  • This study investigates the link between flow-mediated dilatation (FMD) and headache types.

Purpose of the Study:

  • To examine the relationship between flow-mediated dilatation (FMD) and migraine with aura, migraine without aura, and tension-type headache.
  • To assess endothelial function in relation to different headache diagnoses within a population-based sample.

Main Methods:

  • Utilized data from the third Nord-Trøndelag Healthy Study (HUNT3).
  • Measured FMD via ultrasound of the brachial artery in 4739 healthy adults.
  • Analyzed cross-sectional associations between headache diagnoses and FMD using logistic regression.

Main Results:

  • Mean FMD did not significantly differ among headache groups and headache-free controls.
  • Multi-adjusted analyses revealed no consistent association between FMD levels and headache diagnoses.
  • No significant relationship was observed between FMD quintiles and headache groups.

Conclusions:

  • This large cross-sectional study found no relationship between flow-mediated dilatation (FMD) and migraine or other headache diagnoses.
  • The findings apply to otherwise healthy individuals without pulmonary or cardiovascular diseases.
  • Endothelial function does not appear to be associated with common headache disorders in this population.