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Related Experiment Videos

[A preliminary report on stereotactic multi-target limbic leucotomy].

C C Jiang

    Zhonghua Shen Jing Jing Shen Ke Za Zhi = Chinese Journal of Neurology and Psychiatry
    |June 1, 1989
    PubMed
    Summary

    Stereotactic limbic leucotomy improved chronic psychiatric disorders in 80% of patients. This psychosurgery targeted the amygdala, cingulate, and innominate regions, with temporary side effects observed.

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    Regulation of PD-L1: a novel role of pro-survival signalling in cancer.

    Annals of oncology : official journal of the European Society for Medical Oncology·2015

    Area of Science:

    • Neurosurgery
    • Psychiatry
    • Neurology

    Context:

    • Chronic psychiatric disorders, particularly schizophrenia, paranoia, and mania, often present with violent behavior.
    • Limited treatment options exist for severe, refractory cases.

    Purpose:

    • To evaluate the efficacy and safety of stereotactic multitarget limbic leucotomy in patients with chronic psychiatric disorders and violence.

    Summary:

    • Ten patients underwent stereotactic thermocoagulative lesions in the amygdala, anterior cingulate, and innominate regions.
    • Significant improvement was observed in 5 patients, with 3 showing some improvement.
    • Temporary complications included mild paraplegia and sphincter disturbances.

    Impact:

    • Stereotactic limbic leucotomy demonstrates potential as a treatment for severe psychiatric disorders with violence.
    • Understanding target selection and complication causes can refine psychosurgical techniques.

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