Related Experiment Video
Updated: Mar 25, 2026
05:46
Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
Published on: September 20, 2024
864
Amniotic membrane-assisted trabeculectomy for refractory glaucoma with corneal disorders
Kazuhiko Mori1, Yoko Ikeda1, Yuko Maruyama1
1Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
International Medical Case Reports Journal
|February 13, 2016
Summary
Amniotic membrane (AM)-assisted trabeculectomy (TLE) showed initial success in controlling intraocular pressure (IOP) for refractory glaucoma patients with severe corneal disorders. However, long-term IOP control was limited, and ocular surface conditions required careful management.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Corneal Disease Management
Background:
- Refractory glaucoma with severe corneal disorders presents a surgical challenge.
- Trabeculectomy (TLE) is a common glaucoma surgery, but outcomes can be compromised by corneal issues.
- Amniotic membrane (AM) has regenerative properties that may benefit ocular surface healing.
Purpose of the Study:
- To evaluate the efficacy and safety of amniotic membrane (AM)-assisted trabeculectomy (TLE) in patients with refractory glaucoma and severe corneal disorders.
- To assess intraocular pressure (IOP) control, visual acuity, and ocular surface conditions post-surgery.
Main Methods:
- Six patients with refractory glaucoma and severe corneal disorders underwent TLE with AM application.
- Human AM was placed epithelial side up on the corneal surface, sutured, and used to cover the TLE area.
- Postoperative outcomes including IOP, visual acuity, filtering bleb, and ocular surface were monitored.
Main Results:
- Mean IOP decreased from 40.3 mmHg preoperatively to 23.0 mmHg at 1 year postoperatively.
- The need for glaucoma medications significantly reduced from 3.0 to 0.8 drugs at 7 years.
- Some patients experienced worsening of ocular surface conditions or visual acuity during the follow-up period.
Conclusions:
- AM-assisted TLE provided initial moderate IOP control for refractory glaucoma with severe corneal disorders.
- Careful management of ocular surface conditions is crucial in these patients.
- Long-term IOP control may be limited in a subset of patients.
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
01:25Glaucoma: Overview
1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K