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Epiglottic diffuse B-cell malignant lymphoma: A case report.

Hung-Min Chang¹, Chiung-Chon Li¹, Stella Chin-Shaw Tsai²

¹Department of Otolaryngology, Tungs' Taichung Metro Harbor Hospital, Taichung 43503, Taiwan, R.O.C.

Molecular and Clinical Oncology

|February 13, 2016

Summary

This summary is machine-generated.

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A rare case of diffuse large B-cell lymphoma, a type of extranodal non-Hodgkin lymphoma, was found in the epiglottis of a 55-year-old male. The patient successfully responded to the rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) regimen.

Area of Science:

Oncology
Pathology
Otorhinolaryngology

Background:

Extranodal non-Hodgkin lymphoma is uncommon.
The epiglottis is a rare site for lymphoma development.

Purpose of the Study:

To report a rare case of diffuse large B-cell lymphoma originating in the epiglottis.
To describe the diagnostic and therapeutic approach for this rare presentation.

Main Methods:

Video laryngoscopy for tumor identification.
Laryngomicrosurgery with biopsy for histopathological diagnosis.
Immunohistochemistry (CD20, Bcl-2, CD3, CD10, Bcl-1) for lymphoma subtyping.
Treatment with the rituximab with cyclophosphamide + doxorubicin + vincristine + prednisolone (R-CHOP) regimen.

Keywords:

diffuse large B-cell malignant lymphoma epiglottis extranodal non-Hodgkin lymphoma laryngeal lymphoma non-Hodgkin lymphoma

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Main Results:

A tumor of the left epiglottis was identified.
Biopsy confirmed diffuse large B-cell lymphoma, positive for CD20 and Bcl-2, negative for CD3, CD10, and Bcl-1.
The patient completed eight cycles of R-CHOP chemotherapy.

Conclusions:

Diffuse large B-cell lymphoma can rarely occur as an extranodal lymphoma in the epiglottis.
The R-CHOP regimen is an effective treatment for this rare condition.