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Published on: April 28, 2019
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture
Hong Jiang1, Hong Du1, Li M Wang2
1Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University Xi'an, China.
Abstract:
Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS), which is a zoonosis endemic in eastern Asia, especially in China. The reservoir host of HTNV is field mouse (Apodemus agraricus). The main manifestation of HFRS, including acute kidney injury, increases vascular permeability, and coagulation abnormalities. In this paper, we review the current knowledge of the pathogenesis of HFRS including virus factor, immunity factor and host genetic factors. Furthermore, the treatment and prevention will be discussed.
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