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SPATIAL MEMORY IMPAIRMENT AND HIPPOCAMPAL CELL LOSS INDUCED BY OKADAIC ACID (EXPERIMENTAL STUDY)

M Chighladze1, M Dashniani1, G Beselia1

  • 1I. Beritashvili Center of Experimental Biomedicine, Tbilisi; St. Andrew the First-Called Georgian University of Georgian Patriarchate, Tbilisi, Georgia.

Georgian Medical News
|February 13, 2016
PubMed
Summary

Okadaic acid (OA) microinjection into the hippocampus impaired long-term spatial memory in rats, causing significant pyramidal cell loss. This suggests a potential animal model for evaluating anti-dementia drugs.

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