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Updated: Mar 25, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Recent progress in imidoyl radical-involved reactions
Jian Lei1, Jinbo Huang1, Qiang Zhu1
1Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. zhu_qiang@gibh.ac.cn.
Imidoyl radicals are versatile intermediates for synthesizing diverse nitrogen-containing compounds like heterocycles and amines. This review highlights recent advancements in imidoyl radical chemistry over the past decade.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Imidoyl radicals are highly reactive intermediates.
- These radicals are valuable in organic synthesis.
Purpose of the Study:
- To review recent progress in imidoyl radical reactions.
- To highlight applications in synthesizing functionalized molecules.
Main Methods:
- Literature review of studies from the past decade.
- Analysis of reaction mechanisms and synthetic applications.
Main Results:
- Imidoyl radicals enable the synthesis of various heterocycles.
- Applications include the preparation of nitriles, imines, and amines.
- Recent advancements have expanded their synthetic utility.
Conclusions:
- Imidoyl radical chemistry has seen significant development.
- These intermediates offer efficient pathways to complex nitrogenous compounds.
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