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Cyclic (di)nucleotides: the common language shared by microbe and host.

Juyi Gao1, Jianli Tao1, Weili Liang2

  • 1State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Beijing 100871, China.

Current Opinion in Microbiology
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Summary
This summary is machine-generated.

Cyclic (di)nucleotides act as a universal language for cellular communication between microbes and hosts. This review highlights how synthases and phosphodiesterases balance these crucial signaling molecules.

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Area of Science:

  • Molecular Biology
  • Microbiology
  • Biochemistry

Background:

  • Cellular communication is vital for complex activities.
  • Cyclic (di)nucleotides are emerging as a shared molecular language between microbes and hosts.
  • These signaling molecules play a key role in modulating host cell activities.

Purpose of the Study:

  • To review recent insights into cyclic (di)nucleotides.
  • To focus on the regulatory mechanisms of cyclic (di)nucleotide signaling.
  • To highlight the roles of synthases and phosphodiesterases in balancing these molecules.

Main Methods:

  • Literature review of recent advancements in cyclic (di)nucleotide research.
  • Analysis of molecular mechanisms governing cyclic (di)nucleotide synthesis and degradation.
  • Focus on the interplay between microbial and host cellular pathways.

Main Results:

  • Cyclic (di)nucleotides are conserved second messengers with diverse functions.
  • Microbes utilize cyclic (di)nucleotides to influence host cell behavior.
  • Synthases and phosphodiesterases are key regulators controlling cyclic (di)nucleotide levels.

Conclusions:

  • Cyclic (di)nucleotides represent a critical interface for microbe-host interactions.
  • Understanding the balance of these molecules is essential for deciphering cellular communication.
  • Targeting synthases and phosphodiesterases may offer therapeutic strategies.