Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.2K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.2K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.5K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.5K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoantibody profiling of autism spectrum disorder patients with monoamine oxidase a deficiency.

Brain, behavior, & immunity - health·2025
Same author

Theranostic Near-Infrared Monoamine Oxidase Inhibitor (NMI) Protein Binding Interactions with MAOA and Albumin.

Pharmaceutical research·2025
Same author

Early Postnatal Pharmacological Intervention Rescues the Disruption of Developmental Connectivity in MAO-A KO Mice.

Neuroscience bulletin·2024
Same author

Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control.

Cardiovascular research·2024
Same author

Facial Feminization: Perioperative Care and Surgical Approaches.

Plastic and reconstructive surgery·2023
Same author

Five questions on how biochemistry can combat climate change.

BBA advances·2023

Related Experiment Video

Updated: Mar 25, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

16.7K

Monoamine oxidase A (MAO A) inhibitors decrease glioma progression.

Swati Kushal1,2, Weijun Wang3,2, Vijaya Pooja Vaikari1,2

  • 1Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA.

Oncotarget
|February 13, 2016
PubMed
Summary
This summary is machine-generated.

Monoamine Oxidase A (MAO A) inhibitors show promise for treating drug-resistant glioblastomas. These MAO A inhibitors, including NMI, reduced tumor growth and improved survival in preclinical models.

Keywords:
MAO AMAO A inhibitorsTMZ-resistantgliomanear-infrared dye conjugate

Related Experiment Videos

Last Updated: Mar 25, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

16.7K

Area of Science:

  • Oncology
  • Neuroscience
  • Biochemistry

Background:

  • Glioblastoma (GBM) is an aggressive brain tumor.
  • Temozolomide (TMZ) is a standard treatment, but resistance often develops.
  • Monoamine Oxidase A (MAO A) contributes to cancer via reactive oxygen species.

Purpose of the Study:

  • To investigate the role of MAO A in glioblastoma.
  • To evaluate MAO A inhibitors as a therapeutic strategy for TMZ-resistant gliomas.
  • To assess the diagnostic potential of a novel MAO A inhibitor.

Main Methods:

  • Assessed MAO A expression in human glioma tissues and cell lines.
  • Tested MAO A inhibitors (clorgyline, NMI) for cytotoxicity and anti-invasion effects in vitro.
  • Evaluated therapeutic efficacy in an intracranial TMZ-resistant glioma model.
  • Utilized immunocytochemistry to analyze tumor characteristics.

Main Results:

  • MAO A expression was elevated in glioma samples.
  • MAO A inhibitors demonstrated cytotoxicity and reduced glioma cell invasion.
  • Treatment with clorgyline or NMI decreased tumor growth and extended survival in vivo.
  • NMI specifically localized to tumors and showed dual therapeutic and imaging potential.

Conclusions:

  • MAO A inhibitors represent a potential novel therapy for drug-resistant gliomas, as monotherapy or in combination with TMZ.
  • NMI offers a dual function for both glioblastoma treatment and non-invasive imaging.
  • Targeting MAO A is a promising strategy for overcoming therapeutic resistance in glioblastoma.