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Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

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Plexiform Neurofibroma: A Case Report.

Georgi Tchernev¹, Anastasiya Atanasova Chokoeva, James W Patterson

¹From the Polyclinic for Dermatology and Venereology, Medical Faculty, University Hospital Lozenetz, Sofia University (GT); "Onkoderma"-Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria (AAC); Department of Pathology, University of Virginia Health System, Charlottesville, VA (JWP); Medical College, Medical University of Varna, Varna, Bulgaria (IB); Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany (UW); and Internal Medicine Unit, Guastalla Hospital, AUSL Reggio Emilia, Reggio Emilia, Italy (CT).

|February 13, 2016

Summary

This summary is machine-generated.

Plexiform neurofibromas, a variant of neurofibromatosis type 1, can cause significant facial deformity. This case highlights clinical diagnosis and management challenges for this rare condition.

Area of Science:

Medical Genetics
Dermatology
Oncology

Background:

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Plexiform neurofibromas are a subtype of neurofibromatosis type 1 (NF-1), characterized by abnormal growths arising from multiple nerves.

These tumors can lead to significant disfigurement and impact connective tissue and skin folds.

NF-1 affects approximately 1 in 3,000 individuals, with plexiform neurofibromas accounting for about 30% of cases.