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Related Experiment Videos

Ioversol clinical safety summary.

M Benamor1, E M Aten, K D McElvany

  • 1Mallinckrodt Medical, Inc., St. Louis, Missouri 63134.

Investigative Radiology
|June 1, 1989
PubMed
Summary

Ioversol, a new nonionic low-osmolality contrast medium, demonstrated excellent safety and diagnostic efficacy comparable to conventional agents. This new contrast agent was well-tolerated, with fewer adverse effects and no significant impact on renal function.

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Area of Science:

  • Radiology and Imaging
  • Medical Contrast Agents

Background:

  • Nonionic low-osmolality contrast media are increasingly used in medical imaging.
  • Evaluating new contrast agents for safety and efficacy is crucial for clinical practice.

Purpose of the Study:

  • To assess the safety and diagnostic efficacy of ioversol, a novel nonionic low-osmolality contrast medium.
  • To compare ioversol's performance against conventional ionic and other nonionic contrast agents.

Main Methods:

  • Evaluation of double-blind comparative and open-label clinical trials.
  • Inclusion of 1,186 patients receiving ioversol at various iodine concentrations (32%, 24%, 16%).
  • Monitoring of patient tolerance, adverse effects, diagnostic quality, and renal function up to 96 hours.

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Main Results:

  • Ioversol was well tolerated by all patients, exhibiting fewer adverse effects than conventional ionic agents.
  • Diagnostic efficacy of ioversol was comparable to conventional and other nonionic agents.
  • No clinically or statistically significant changes in renal function were observed.

Conclusions:

  • Ioversol is a safe and effective nonionic low-osmolality contrast medium.
  • Its improved patient tolerance may enhance radiograph quality.
  • Ioversol presents a viable alternative for diagnostic imaging procedures with a favorable safety profile.