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Cortical Gyrification Patterns Associated with Trait Anxiety.

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High trait anxiety is linked to reduced cortical complexity in the brain's left superior parietal cortex. This finding suggests altered brain development and connectivity may underlie anxiety disorders.

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Area of Science:

  • Neuroscience
  • Psychology
  • Brain Imaging

Background:

  • Dispositional anxiety is a personality trait linked to internalizing disorders.
  • Abnormal cortical folding may indicate altered brain development and connectivity.
  • Previous research noted structural brain differences in anxiety, but gyrification remains unexplored.

Purpose of the Study:

  • To investigate the relationship between trait anxiety and cortical gyrification.
  • To explore if local gyrification index (LGI) differs based on anxiety levels.
  • To understand the neural correlates of trait anxiety for disorder development insights.

Main Methods:

  • Structural MRI scans were acquired from 113 young adults.
  • The local gyrification index (LGI) was used to measure cortical complexity.
  • Trait anxiety levels were assessed and correlated with LGI.

Main Results:

  • A negative correlation was found between trait anxiety and LGI.
  • Reduced cortical complexity (lower LGI) was observed in the left superior parietal cortex (precuneus) in individuals with higher trait anxiety.
  • This region is part of the default mode network.

Conclusions:

  • Aberrations in cortical gyrification, particularly in the precuneus, are associated with trait anxiety.
  • Altered gyrification may reflect disrupted local connectivity in the parietal lobe.
  • These findings offer insights into the neurodevelopmental underpinnings of trait anxiety.