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Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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Irritable Bowel Syndrome III: Medical and Nursing Management01:30

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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Related Experiment Video

Updated: Mar 25, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
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[Irritable bowel syndrome: New pathophysiological hypotheses and practical issues].

H Duboc1, M Dior2, B Coffin2

  • 1Service d'hépato-gastro-entérologie, hôpital Louis-Mourier, AP-HP, 178, rue des Renouillers, 92700 Colombes, France; UMR 1149, centre de recherche sur l'inflammation, université Paris VII, Sorbonne Paris Cité, 16, rue Henri-Huchard, 75018 Paris, France; Faculté Denis-Diderot - Paris 7, 75006 Paris, France.

La Revue De Medecine Interne
|February 14, 2016
PubMed
Summary

Irritable bowel syndrome (IBS) management has advanced, focusing on the brain-gut axis and a low-FODMAP diet. Diagnosis emphasizes clinical criteria over excessive testing for improved patient quality of life.

Keywords:
Axe cerveau-intestinBrain-gut axisCritères de RomeFODMAPFODMAPsGut microbiotaHypersensibilité viscéraleIntestin irritableIrritable bowel syndromeMicrobiote intestinalROME criteriaSerotoninSérotonineVisceral hypersensitivity

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Area of Science:

  • Gastroenterology
  • Neurogastroenterology
  • Microbiome research

Background:

  • Irritable bowel syndrome (IBS) remains a prevalent condition impacting patient quality of life.
  • Recent advancements have refined understanding of IBS pathophysiology and diagnosis.
  • The role of diet in IBS symptomology is increasingly recognized.

Purpose of the Study:

  • To summarize the evolving understanding of irritable bowel syndrome (IBS) in 2015.
  • To highlight the central role of the brain-gut axis in IBS.
  • To emphasize evidence-based diagnostic and dietary approaches for IBS.

Main Methods:

  • Review of current literature and clinical consensus on IBS.
  • Explanation of the brain-gut axis hypothesis integrating peripheral and central factors.
  • Discussion of diagnostic criteria (Rome III) and the importance of clinical judgment.
  • Evaluation of dietary interventions, specifically low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diets.

Main Results:

  • The brain-gut axis provides a unifying framework for IBS pathophysiology, linking gut factors (microbiota, serotonin) to central pain processing.
  • Clinical diagnosis based on Rome III criteria is recommended, avoiding unnecessary investigations when red flags are absent.
  • A low-FODMAP diet has demonstrated positive and reproducible results in managing IBS symptoms.

Conclusions:

  • IBS understanding has significantly evolved, centering on the brain-gut axis.
  • Prudent diagnostic strategies and evidence-based dietary interventions like the low-FODMAP diet are crucial for effective IBS management.
  • These advancements offer improved quality of life for IBS patients.