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S100A7: A rAMPing up AMP molecule in psoriasis
Fabio D'Amico1, Evangelia Skarmoutsou1, Mariagrazia Granata1
1Department of Biomedical and Biotechnological Sciences, University of Catania, Italy.
Cytokine & Growth Factor Reviews
|February 14, 2016
Summary
S100A7 (psoriasin) protein amplifies inflammation in psoriasis, a chronic skin disease. Targeting S100A7 may offer a new therapeutic strategy for managing psoriatic skin inflammation.
Area of Science:
- Biochemistry
- Immunology
- Dermatology
Background:
- S100A7 (psoriasin) is a calcium-binding protein in epithelial cells.
- Its overexpression is linked to inflammatory conditions like psoriasis.
- S100A7 is implicated in amplifying inflammatory processes in psoriatic skin.
Purpose of the Study:
- To review the interactions between S100A7 and cytokines in psoriatic skin.
- To focus on the regulation and functions of S100A7 in psoriasis.
- To discuss S100A7 as a potential therapeutic target for psoriasis.
Main Methods:
- Literature review of S100A7 in psoriasis.
- Analysis of S100A7 interactions with cytokines.
- Discussion of S100A7 regulation and function.
Main Results:
- S100A7 plays a critical role in amplifying inflammation in psoriatic skin.
- Evidence suggests S100A7 perpetuates the disease phenotype.
- Specific interactions between S100A7 and cytokines are key to its function.
Conclusions:
- S100A7 is a significant mediator of inflammation in psoriasis.
- Understanding S100A7 regulation and function is crucial.
- S100A7 presents a promising therapeutic target for psoriasis treatment.
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