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Updated: Mar 25, 2026

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
Published on: October 26, 2018
Acidity-Activated Shielding Strategies of Cationic Gene Delivery for Cancer Therapy
Jialiang Xia1, Zongcai Feng, Hongyan Yang
1School of Chemistry and Chemical Engineering, Lingnan Normal University, 29 Cunjin Road, Zhanjiang, Guangdong 524048, PR China. xiajl105@126.com.
Abstract:
Cationic gene vectors increased attractive for gene therapy. However, unstable systemic circulation due to the interaction of gene delivery system with blood cells limited the further application. Therefore, pH sensitive shielding systems were exploited, by which, the positive surface charge density of polyplexes was reduced, circulation time was improved and pH-triggered targeting delivery was promised. This mini review mainly focuses on the development of solid tumors pH environment activated shielding systems for cationic gene vectors. This shielding strategy shows great potential for enhancing efficient gene transporting and achieving better therapeutic effects in acidic tumor treatment.
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