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Flibanserin.

Ximena Vallejos1, Christine Wu1

  • 11 Miami VA Healthcare System, Miami, FL, USA.

Journal of Pharmacy Practice
|February 14, 2016
PubMed
Summary
This summary is machine-generated.

Flibanserin effectively treats hypoactive sexual desire disorder (HSDD) in premenopausal women by improving sexual desire and satisfying sexual events. Common side effects include somnolence, dizziness, and nausea.

Keywords:
flibanserinhypoactive sexual desire disorderpremenopausal women

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Area of Science:

  • Pharmacology
  • Clinical Trials
  • Women's Health

Background:

  • Hypoactive sexual desire disorder (HSDD) affects premenopausal women.
  • Flibanserin is a novel, nonhormonal agent targeting neurotransmitters.

Purpose of the Study:

  • Review clinical trials on flibanserin for HSDD in premenopausal women.
  • Summarize pharmacology, contraindications, precautions, and patient education.

Main Methods:

  • Literature search of PubMed, FDA website, and ClinicalTrials.gov.
  • Included randomized, double-blind, placebo-controlled trials published March 2012-June 2014.
  • Focused on English-language studies involving human subjects.

Main Results:

  • Three trials showed flibanserin improved desire and satisfying sexual events in premenopausal women.
  • One trial evaluated postmenopausal women.
  • Most common adverse events: somnolence, dizziness, nausea.

Conclusions:

  • Flibanserin demonstrates efficacy in improving sexual desire and satisfying sexual events in premenopausal women with HSDD.
  • It acts as a nonhormonal agent modulating neurotransmitters.