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Effects of dihydroergotamine on psychomotor function, neuroendocrine parameters and blood pressure, in healthy
P Danjou1, L Lacomblez, D Warot
1Service de Pharmacologie, Division Ambroise Paré, Hôpital de la Salpêtrière, Paris, France.
International Clinical Psychopharmacology
|January 1, 1989
Abstract:
Following the infusion of 15 micrograms/kg of dihydroergotamine (DHE) a 50-fold rise in growth hormone plasma levels was observed in 9 healthy volunteers. Prolactin (PRL) secretion was depressed 240 minutes post infusion. For 170 min, diastolic blood pressure was increased reaching a peak of +19 mmHg at the end of the infusion. Mild sedation and nausea were induced by the treatment for a total duration of 60 min.