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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
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Extremity soft tissue sarcoma with multiple primary malignancies--Characteristics and outcome
C L L Lopez-Oliva1, J Y Yun1, H-S Kim1
1Department of Orthopaedic Surgery, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, Seoul 03080, South Korea.
Summary
Multiple primary malignancies (MPM) occur in 6% of extremity soft tissue sarcoma (STS) patients. Older age at diagnosis is a risk factor, but survival outcomes for STS are similar between patients with and without MPM.
Area of Science:
- Oncology
- Surgical Oncology
- Cancer Epidemiology
Background:
- Multiple primary malignancies (MPM) impact treatment and surveillance strategies for extremity soft tissue sarcoma (STS).
- Understanding the incidence and characteristics of MPM in STS is crucial for patient management.
Purpose of the Study:
- To determine the incidence of MPM in patients with extremity STS (MPM-STS).
- To compare clinicopathologic features and survival outcomes between MPM-STS patients and those with STS only.
Main Methods:
- Retrospective review of 585 patients undergoing surgery for extremity STS.
- Logistic regression analysis to identify risk factors for MPM development.
- 1:2 matched case-control analysis to compare survival outcomes.
Main Results:
- 34 patients (6%) were diagnosed with MPM.
- Older age (>49 years) at STS diagnosis was a significant risk factor for MPM (OR=2.5, p=0.029).
- Cancer-specific survival was lower in the MPM-STS group, but STS-specific survival did not differ significantly.
Conclusions:
- MPM is a notable comorbidity in extremity STS.
- Older age at STS diagnosis is associated with an increased risk of MPM.
- Prognosis for STS appears similar regardless of MPM status.
