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A unique macrolactam derivative via a [4+6]-cycloaddition from Streptomyces niveus

Liya Li1, Yaping Cai1, Yi Jiang2

  • 1Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, PR China.

Bioorganic & Medicinal Chemistry Letters
|February 15, 2016
PubMed
Summary

Researchers discovered two new compounds, nivelactam and niveamide, from Streptomyces niveus bacteria found in Chinese forest soil. Nivelactam showed moderate cytotoxic activity against human tumor cell lines in laboratory tests.

Keywords:
CycloadditionCytotoxicityIn vitroMacrolactamStreptomyces niveus

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