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Toxicity testing of sealants: a tissue implant study
The Journal of Pedodontics
|January 1, 1989
Summary
Pit and fissure sealants showed mild foreign body reactions in guinea pigs, resolving within 12 weeks. Both Delton and Concise White sealant materials, whether autopolymerized or photopolymerized, demonstrated similar tissue responses.
Area of Science:
- Biomaterials Science
- Dental Materials
- Toxicology
Background:
- Pit and fissure sealants are crucial for preventing dental caries.
- Assessing the biocompatibility and tissue response of dental materials is essential for patient safety.
Purpose of the Study:
- To evaluate the subcutaneous tissue toxicity of Delton and Concise White pit and fissure sealants in guinea pigs.
- To determine the short-term and long-term tissue reactions following sealant implantation.
Main Methods:
- Subcutaneous implantation of Delton and Concise White sealants (autopolymerized and photopolymerized) into guinea pigs.
- Histopathological evaluation of tissue reactions at two and 12 weeks post-implantation.
- Adherence to the ADA/ANSI Document No. 41, 1982 protocol for toxicity testing.
Main Results:
- Mild to moderately severe foreign body reactions and reactive fibrosis were observed at two weeks.
- By 12 weeks, tissue reactions subsided, characterized by thin fibrous walls with minimal chronic inflammation.
- Both Delton and Concise White materials, regardless of polymerization method, elicited comparable tissue responses.
Conclusions:
- Subcutaneous implantation of pit and fissure sealants induces a transient foreign body reaction, resolving by 12 weeks.
- Initial reactive fibrosis evolves into a thin fibrous capsule, indicating good biocompatibility.
- Delton and Concise White sealants exhibit similar, generally mild, tissue compatibility profiles.
