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Direct oral anticoagulants in rare venous thrombosis

Guido Finazzi1, Walter Ageno2

  • 1USS Malattie Mieloproliferative Croniche, USC Ematologia, Ospedale Papa Giovanni XXIII, Piazza OMS 1, 24127, Bergamo, Italy. gfinazzi@hpg23.it.

Internal and Emergency Medicine
|February 15, 2016
PubMed

Insights

Direct oral anticoagulants (DOACs) show promise for treating rare venous thrombosis like abdominal or cerebral cases. Ongoing studies are evaluating their efficacy and safety in these conditions.

Area of Science:

  • Cardiology
  • Hematology
  • Vascular Medicine

Background:

  • Direct oral anticoagulants (DOACs) like dabigatran, rivaroxaban, and apixaban are standard for limb or pulmonary venous thromboembolism.
  • Their application in abdominal or cerebral venous thrombosis is less established due to limited data.

Purpose of the Study:

  • To review current clinical experience with DOACs in rare venous thrombosis.
  • To provide updates on ongoing clinical trials investigating DOACs for these conditions.

Main Methods:

  • Review of published case reports and small patient series.
  • Analysis of data from prospective cohort studies and randomized controlled trials.

Main Results:

  • Existing data from case reports and small series suggest DOACs are effective and safe for rare venous thrombosis.
  • Ongoing trials aim to provide more robust evidence for DOAC use in these indications.

Conclusions:

  • DOACs demonstrate potential for treating abdominal and cerebral venous thrombosis.
  • Further research through prospective studies and trials is crucial to confirm their role in rare venous thrombosis.

Keywords:
Abdominal venous thrombosisApixabanCerebral venous thrombosisDabigatranRivaroxaban

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