Related Experiment Video
Updated: Aug 17, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
Published on: April 21, 2012
Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis)
C Pirmez1, M C Marzochi, S G Coutinho
1Instituto Oswaldo Cruz, Escola Nacional de Saúde Pública--FIOCRUZ, Rio de Janeiro, Brasil.
Abstract:
Four mongrel dogs were intradermically inoculated with 3 x 10(6) Leishmania braziliensis braziliensis promastigotes. Three out of the four animals developed cutaneous lesions respectively 4, 7, and 8 months after. The fourth dog did not develop lesion at the inoculation site, but a mucosal ulcer was seen 16 months after the inoculum. Clinical, histopathological, and serological findings were similar to what is found in natural canine infection as well as in the human disease. These results suggest that dogs may be an useful model for L. b. braziliensis infection.
Related Concept Videos
Leishmaniasis
American Trypanosomiasis
Antiprotozoal Agents

