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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Related Experiment Video

Updated: Mar 25, 2026

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer
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Community-Based Multidisciplinary Computed Tomography Screening Program Improves Lung Cancer Survival.

Daniel L Miller1, William R Mayfield1, Theresa D Luu1

  • 1Multidisciplinary Thoracic Oncology Program, WellStar Health System/Mayo Clinic Care Network, Marietta, Georgia.

The Annals of Thoracic Surgery
|February 16, 2016
PubMed
Summary
This summary is machine-generated.

Community-based lung cancer CT screening improves survival by detecting cancer earlier. This program benefits patients at moderate to high risk, even those not meeting National Lung Screening Trial criteria.

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Area of Science:

  • Oncology
  • Radiology
  • Public Health

Background:

  • Lung cancer is a leading cause of cancer mortality in the US, often diagnosed at advanced stages.
  • Computed tomography (CT) screening has shown potential to reduce lung cancer mortality in high-risk individuals.
  • The need exists to validate CT screening effectiveness in community settings.

Purpose of the Study:

  • To evaluate the efficacy of a community-based CT lung cancer screening program.
  • To determine if survival advantages seen in academic centers can be replicated in a community healthcare system.
  • To assess the impact of CT screening on early-stage cancer detection and patient survival.

Main Methods:

  • A CT lung cancer screening program was implemented in the WellStar Health System (WHS) from 2008 to 2013.
  • Screening criteria included International Early Lung Cancer Action Program and National Comprehensive Cancer Network guidelines.
  • Data from 1,267 screened individuals were analyzed.

Main Results:

  • 41% of screened individuals had indeterminate pulmonary nodules; 2.8% underwent diagnostic procedures.
  • Lung cancer was diagnosed in 2.2% of screened individuals, with 75% in early stages (I or II).
  • Five-year overall survival was 64% and cancer-specific survival was 71% in screened patients, significantly higher than the 19% survival in non-screened patients.

Conclusions:

  • Community-based lung cancer CT screening programs can enhance patient survival.
  • Screening facilitates an important stage shift towards earlier cancer detection.
  • CT screening may benefit a broader population at moderate or high risk, beyond strict National Lung Screening Trial criteria.