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Cannabinoids and autoimmune diseases: A systematic review
Valeria Katchan1, Paula David2, Yehuda Shoenfeld3
1Departamento de Medicina Interna, Hospital La Paz, Madrid, Spain; Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Autoimmunity Reviews
|February 16, 2016
Summary
Cannabinoids show immunosuppressive properties, reducing inflammation and pain in preclinical models. Further human studies are needed to confirm their potential for autoimmune disorders.
Area of Science:
- Immunology
- Pharmacology
Background:
- Cannabinoids interact with CB1 and CB2 receptors, modulating neurotransmitter and cytokine release.
- Current research indicates cannabinoids possess immunosuppressive properties.
Purpose of the Study:
- To review the role of cannabinoids in the immune system.
- To explore their potential therapeutic applications in autoimmune disorders.
Main Methods:
- Review of existing research on cannabinoid effects on immune cells and preclinical models.
- Analysis of studies investigating cannabinoid efficacy in inflammatory and autoimmune conditions.
Main Results:
- Cannabinoids inhibit leucocyte proliferation, induce T cell and macrophage apoptosis, and reduce pro-inflammatory cytokine secretion.
- Preclinical studies demonstrate effectiveness in arthritis, multiple sclerosis, neuropathic pain, type 1 diabetes, fibromyalgia, and scleroderma.
Conclusions:
- Cannabinoids exhibit promising immunosuppressive and anti-fibrotic effects.
- Human studies are limited, necessitating further research for clinical application in autoimmune diseases.
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