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Related Experiment Video

Updated: Mar 25, 2026

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Published on: December 29, 2023

Tissue factor as a link between inflammation and coagulation.

Marco Witkowski¹, Ulf Landmesser¹, Ursula Rauch¹

¹Department of Cardiology, Medical Clinic II, Charité Universita tsmedizin, Campus Benjamin Franklin, Berlin, Germany.

Trends in Cardiovascular Medicine

|February 16, 2016

Summary

This summary is machine-generated.

Tissue factor (TF) initiates blood clotting and is induced by inflammation. Modulating TF expression and splicing can alter blood vessel responses and inflammation.

Keywords:

Coagulation Endothelium Inflammation Tissue factor Vessel

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Published on: February 14, 2017

Area of Science:

Biochemistry
Immunology
Vascular Biology

Background:

Tissue factor (TF) is the primary initiator of the blood coagulation cascade, crucial for hemostasis.
TF expression is upregulated by inflammatory cytokines in endothelial and blood cells.
TF possesses signaling functions beyond coagulation, influencing inflammatory responses.

Purpose of the Study:

To investigate the role of tissue factor (TF) in initiating blood coagulation and hemostasis.
To examine the impact of inflammatory cytokines on TF expression, including alternative splicing.
To explore the signaling activities of TF and its influence on inflammatory responses in the vasculature.

Main Methods:

Analysis of TF receptor activity for factor VII.
Assessment of inflammatory cytokine-induced expression of full-length and alternatively spliced TF.
Investigation of TF's signaling pathways via protease-activated receptors.

Main Results:

TF is confirmed as the primary initiator of the coagulation cascade, ensuring rapid hemostasis.
Inflammatory cytokines significantly induce both full-length and alternatively spliced TF.
TF signaling contributes to pleiotropic inflammatory responses.

Conclusions:

Alterations in TF expression and alternative splicing can modify the endothelial cell phenotype.
Modulating TF offers a potential strategy to control inflammatory responses within blood vessels.