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Updated: Mar 25, 2026

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
Published on: April 17, 2017
Hepatitis C virus relies on lipoproteins for its life cycle
Germana Grassi1, Giorgia Di Caprio1, Gian Maria Fimia1
1Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
Abstract:
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.
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